This guy is really giving his mind to art. Bryan Lewis Saunders made a whole collection of self-portraits while tripping on drugs. He did A LOT of drugs.
These mind-blowing portraits were made on a vast array of different substances, ranging from anti-depressants, to salvia, to "prison wine."
Saunders writes that he took a different drug every day to see how it affected his self-perception. Within weeks, he "became lethargic and suffered mild brain damage" so do I really need to recommend you don't try this experiment at home?
Today, he continues the experiment, but only with drugs he's given by medical professionals for unrelated health problems.